SYNGR4 AND PLEKHB1 DEREGULATION IN MOTOR NEURONS OF AMYOTROPHIC LATERAL SCLEROSIS MODELS: POTENTIAL CONTRIBUTIONS TO PATHOBIOLOGY

SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology

Amyotrophic lateral nef rune sclerosis is the most common adult-onset neurodegenerative disease affecting motor neurons.Its defining feature is progressive loss of motor neuron function in the cortex, brainstem, and spinal cord, leading to paralysis and death.Despite major advances in identifying genes that can cause disease when mutated and model

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Improving the Assessment of Mild Cognitive Impairment in Advanced Age With a Novel Multi-Feature Automated Speech and Language Analysis of Verbal Fluency

Introduction: Clinically relevant information can go uncaptured in the conventional scoring of a verbal fluency test.We hypothesize that characterizing the temporal aspects of the response through a set of time related measures will be useful in distinguishing those with MCI from cognitively intact controls.Methods: Audio recordings of an animal fl

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Platelets are critical for survival and tissue integrity during murine pulmonary Aspergillus fumigatus infection.

Beyond their canonical roles in hemostasis and thrombosis, platelets function in the innate immune response by interacting directly with pathogens and by regulating the recruitment and activation of immune effector cells.Thrombocytopenia often coincides with neutropenia in patients with hematologic malignancies and in allogeneic hematopoietic cell

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Exploring strong controlled partial metric type spaces: Analysis of fixed points and theoretical contributions

This study involves the generalization of partial metric spaces and strong controlled metric type spaces through the introduction of the ill tempered gnome notion of strong controlled partial metric type spaces.This research pursues a dual objective: firstly, to scrutinize fixed points related to contractions of the Kannan type within the framework

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